Preparation method of levothyroxine sodium oral liquid

The invention belongs to the field of preparation of medical preparations characterized by oral liquid, and particularly relates to a preparation method of levothyroxine sodium oral liquid. According to the invention, the nano-precipitated drug is obtained by adopting an anti-solvent precipitation method, the solubility of the levothyroxine sodium bulk drug is improved, the process is simple, the effect is better, the levothyroxine sodium bulk drug can be uniformly dispersed in the suspension solvent, the suspension solvent can further stabilize the performance of the nano-precipitated drug, and the bioavailability of levothyroxine sodium is improved. The levothyroxine sodium oral liquid disclosed by the invention is relatively wide in storage environment and relatively stable in property, can well solve the problem that the dosage of tablets is not easy to control, and is suitable for a wide range of people. 本发明属于以口服液为特征的医药配置品制备领域，具体涉及一种左甲状腺素钠口服液的制备方法。本发明采用抗溶剂沉淀法获得纳米沉淀药物，提升左甲状腺素钠原料药的溶解性，工艺简单，效果较佳，能在悬浮溶媒剂中实现均