Ionizable lipid compound, nucleic acid drug molecule delivery system and application

The invention provides an ionizable lipid compound, a nucleic acid drug molecule delivery system and application. In order to provide more good nucleic acid vaccine delivery vectors capable of meeting requirements, the invention develops an ionizable lipid compound suitable for nucleic acid drugs or vaccines in the forms of mRNA, siRNA, ASO, linear DNA or annular plasmid DNA and the like, and a composition of the ionizable lipid compound. The formula formed by the ionizable lipid compound and the composition thereof can effectively encapsulate nucleic acids in several forms such as mRNA and the like to form nano-particles, and the nano-particles are delivered to in-vivo or in-vitro cells to realize high-level protein translation. The nucleic acid delivery efficiency is high, the tissue/organ targeting property is good, the activity of an immune system can be effectively stimulated, and the polypeptide can be applied to protein replacement therapy, preventive or therapeutic vaccines and the like. 本发明提供一种可离子化脂质