M6PR cell surface receptor binding compounds and conjugates

The present disclosure provides a class of compounds comprising a ligand moiety that specifically binds to the mannose-6-phosphate receptor (M6PR) on the surface of a cell. The M6PR binding compound can trigger the receptor to internalize the bound compound into a cell. Ligand moieties of the present disclosure may be linked to a variety of moieties of interest without affecting specific binding to the M6PR as well as the function of the M6PR. Also provided are compounds that are conjugates of a ligand moiety linked to a biomolecule, such as an antibody, that can utilize a cellular pathway to remove specific target proteins from the cell surface or the extracellular environment. For example, the conjugates described herein can sequester and/or degrade a target molecule of interest in a cytolysosome. Methods of targeting proteins for isolation and/or lysosomal degradation using the conjugates are also provided. 本公开提供了一类包含特异性地结合到细胞表面甘露糖-6-磷酸酯受体(M6PR)的配体部分的化合物。所述M6PR结合化合物可以触发所述受体将结合的化合物内化到细胞中。本公开的配体部分可以与多种感兴趣的部分