Method for realizing deuterated methylation of cysteine-containing polypeptide based on micro-flow field reaction technology

The invention discloses a method for realizing deuterated methylation of cysteine-containing polypeptide based on a micro-flow field reaction technology, which comprises the following steps of: reacting a homogeneous solution containing a cysteine-containing polypeptide compound as shown in a formula 1, a deuterated methylation reagent as shown in a formula 2, an alkali additive and a solvent in a micro-flow field reaction device; the cysteine polypeptide deuterated methylation modified product as shown in the formula 3 is obtained. The deuterated methylation reagent developed by the invention is simple in structure and stable in property, and can be synthesized from commercial raw materials through simple steps, so that the preparation difficulty and the raw material cost are reduced; the method effectively overcomes the ubiquitous problems of complex operation steps, long reaction time, need of expensive catalysts, low atom economic efficiency and the like existing in traditional deuterated methylation reag