Imidazolopyrimidines and triazolopyrimidines as A2A/A2B inhibitors

Imidazolopyrimidines and triazolopyrimidines as A2A/A2B inhibitors

The present application relates to compounds of formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as the subtype A2A and A2B receptors, and are useful in the treatment of diseases associated with the activity of adeno...

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Hauptverfasser: HAN HANNA, ZHAO LIHUA, YU ZHEYONG, HUANG TAO, WANG XIAOZHAO, GAIN PHILIPPE, QI CHAO, QIAN DING-QUAN, MCCAMMAN, MICHAEL, S, YAO WENQING, HE CHUNHONG, WU LIANGXING, ZHANG FENGLEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present application relates to compounds of formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as the subtype A2A and A2B receptors, and are useful in the treatment of diseases associated with the activity of adenosine receptors, including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. # imgabs0 # 本申请涉及式(I)化合物或其药学上可接受的盐或立体异构体，其调节腺苷受体诸如亚型A2A和A2B受体的活性且可用于治疗与腺苷受体的活性相关的疾病，包括例如癌症、炎性疾病、心血管疾病和神经变性疾病。#imgabs0#