1-substituent-5-amino-4-pyrazole acylhydrazone compound and application thereof in prevention and treatment of tobacco mosaic virus disease

The invention discloses a 1-substituent-5-amino-4-pyrazole acylhydrazone compound. The 1-substituent-5-amino-4-pyrazole acylhydrazone compound is characterized in that the structural formula of the 1-substituent-5-amino-4-pyrazole acylhydrazone compound is as follows: # imgabs0 #, wherein R1 is phenyl or tertiary butyl; and R2 is phenyl or substituted phenyl. According to the invention, a series of 1-substituent-5-amino-4-pyrazole acylhydrazone compounds are designed and synthesized, and the in vivo experiment of the compounds shows that the compounds have good treatment, protection and passivation activity on virus diseases caused by tobacco mosaic virus (TMV). And compared with other similar compounds, the compound shows better therapeutic activity. 本发明公开了一类1-取代基-5-氨基-4-吡唑酰腙类化合物，其特征在于：其结构式如下：#imgabs0#其中R1为苯基或叔丁基；R2为苯基或取代苯基。本发明设计、合成了系列1-取代基-5-氨基-4-吡唑酰腙类化合物，通过化合物的活体实验发现，该类化合物对烟草花叶病毒(TMV)引起的病毒病具有良好的治疗、保护和钝化活性。且与同类其它化合物相比，表现出较好的治疗活性。