Application of captopril in preparation of medicine for treating sodium hypochlorite induced human bronchial epithelial cell injury

The invention belongs to the technical field of biological medicine, and discloses application of captopril in preparation of a medicine for treating sodium hypochlorite induced human bronchial epithelial cell injury, and captopril has a remarkable effect on protecting the survival rate of sodium hypochlorite induced human bronchial epithelial cells. By inhibiting cell apoptosis, controlling generation of active oxygen, reducing the level of MDA (malondialdehyde) and adjusting the protein expression quantity of three antioxidant enzymes, namely Keap-1, Nrf-2 and HO-1, the SOD (superoxide dismutase) activity of the antioxidant enzymes and the IL-1 beta mRNA (messenger ribonucleic acid) level of knots, the BEAS-2B cell injury induced by NaClO can be protected. The invention provides a new thought for preventing and treating sodium hypochlorite induced human bronchial epithelial cell injury by captopril. 本发明属于生物医药技术领域，公开了卡托普利在制备治疗次氯酸钠诱导的人支气管上皮细胞损伤药物中的应用，卡托普利在保护次氯酸钠诱导的人支气管上皮细胞存活率具有显著作用，可通过通过抑制细胞凋亡、控活性氧的生成、降低MDA的水