Application of sodium butyrate in prevention and/or treatment of lead poisoning

The invention relates to an application of sodium butyrate in prevention or treatment of lead neurotoxicity. Researches show that sodium butyrate has an obvious improvement effect on neurological behavior damage and neuroinflammatory response caused by chronic lead poisoning, and sodium butyrate can...

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Bibliographische Detailangaben
Hauptverfasser: MENG XIAOJING, LI YUNTING, LIU ANFEI, CHEN KAIJU, FAN HONGYING, ZENG WEISEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an application of sodium butyrate in prevention or treatment of lead neurotoxicity. Researches show that sodium butyrate has an obvious improvement effect on neurological behavior damage and neuroinflammatory response caused by chronic lead poisoning, and sodium butyrate can also improve reduction of neurotrophic factors BDNF caused by chronic lead exposure. The new application of the sodium butyrate provides a novel drug choice for the treatment of chronic lead poisoning, especially the treatment of lead neurotoxicity, and has great application potential and value. 本发明涉及一种丁酸钠在预防或治疗铅神经毒性中的应用。本发明研究显示,丁酸钠对慢性铅中毒引起的神经行为损伤、神经炎症反应有明显的改善作用,丁酸钠可还改善慢性铅暴露引起的神经营养因子BDNF的降低。本发明丁酸钠的新应用,为慢性铅中毒的治疗,尤其是铅神经毒性方面的治疗,提供了一种新型药物选择,并具有很大的应用潜力与价值。