Immune-related predictive gene of renal fibrosis and application thereof

The invention discloses an immune related predictive gene of renal fibrosis. The Hub gene comprises one or a combination of more of CD40, TLR2, PTPRC, ICAM1, IL1B, CCL5, STAT1, CD86, CD8A or CCR5. According to the method, differential expression genes are obtained through a'lima 'R packet,...

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Bibliographische Detailangaben
Hauptverfasser:	LIU BUHUI, ZHAO SI, ZHU JINGJING, HE WEIMING, ZHANG AOXUE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an immune related predictive gene of renal fibrosis. The Hub gene comprises one or a combination of more of CD40, TLR2, PTPRC, ICAM1, IL1B, CCL5, STAT1, CD86, CD8A or CCR5. According to the method, differential expression genes are obtained through a'lima 'R packet, enrichment scores of immune cells in each sample are analyzed and calculated through CIBERSORT, related modules and genes of the differential infiltration immune cells are found by adopting weighted gene co-expression network analysis and an ImmPort database, central genes of a protein-protein interaction network are identified through an MCODE plug-in, and the protein-protein interaction network is obtained. A working characteristic curve of a subject is used for verifying the diagnostic value of the Hub gene, a non-coding RNA (miRNA)-Hub gene and transcription factor (TF)-hub gene regulation network is used for explaining the regulation mechanism of the Hub gene, and finally the expression of the Hub gene in a verificatio