Improved respiratory syncytial virus fusion F protein mutant and application thereof

The invention relates to the field of biological medicine, in particular to an improved respiratory syncytial virus fusion F protein mutant and application thereof. According to the respiratory syncytial virus fusion F protein mutant provided by the invention, a trimer structure can be formed on the premise of not introducing a heterotrimerization structural domain, and meanwhile, by virtue of mutation designs such as release of electrostatic repulsive force in the protein, deletion of a furin restriction enzyme cutting site, shearing of a C-terminal structural domain and introduction of an inter-chain disulfide bond, the fusion F protein can be obtained. The conformation can be stabilized before fusion, and the protein is more stable. The respiratory syncytial virus F protein mutant has high immunogenicity when being used as a vaccine or a vaccine component, can induce an immunized animal to generate a high-level neutralizing antibody, can be used for preparing a vaccine for preventing respiratory syncytial