Sunitinib malate impurity reference substance as well as preparation method and application thereof

The invention discloses a sunitinib malate impurity reference substance and a preparation method and application thereof.The sunitinib malate impurity reference substance is a compound A # imgabs0 #. The sunitinib malate impurity reference substance compound A prepared through a synthesis method is high in purity and can be prepared in a large-scale mode; the method can be used for detecting and controlling impurities in sunitinib malate, and provides a basis for quality research of sunitinib malate bulk drugs and preparations. 本发明公开了一种苹果酸舒尼替尼杂质对照品及其制备方法和应用，所述苹果酸舒尼替尼杂质对照品为化合物A#imgabs0#本发明使用合成方法来制备苹果酸舒尼替尼杂质对照品化合物A，纯度高，并且能够大量制备，能用于检测控制苹果酸舒尼替尼中的杂质，为苹果酸舒尼替尼原料药和制剂的质量研究提供了基础。