Application of gallic acid in preparation of medicine for treating or preventing Alzheimer disease

The invention discloses application of gallic acid in preparation of a medicine for treating or preventing Alzheimer's disease, and relates to the technical field of medicine application. The gallic acid has the capacity of inhibiting beta amyloid protein aggregation, primary microglial cells cultured in the cerebral cortex of a C57BL-6 suckling mouse are applied through a combined biological experiment, and it is verified that the gallic acid can inhibit beta amyloid protein aggregation, regulate the mitochondrial metabolism function of the microglial cells, and inhibit beta amyloid protein aggregation. The gallic acid has the effects of promoting immunoregulation such as phagocytosis and elimination of microglia on beta amyloid protein, can effectively inhibit neuroinflammation caused by beta amyloid protein, and expands the application of gallic acid in Alzheimer's disease. 本发明公开了一种没食子酸在制备治疗或预防阿尔茨海默病药物中的应用，涉及药物应用技术领域。本发明采用没食子酸具有抑制β淀粉样蛋白聚集的能力外，通过联合生物实验应用C57BL-6乳鼠大脑皮层中培养的原代小胶质细胞，验证没食子酸通过抑制β淀粉样蛋白聚集，调节小胶质细胞线粒体