Mannose self-assembly nanoparticles as well as preparation method and application thereof

The invention belongs to the technical field of nanoparticles, discloses mannose self-assembled nanoparticles as well as a preparation method and application thereof, and particularly discloses mannose self-assembled nanoparticles, and the mannose self-assembled nanoparticles are formed by self-assembling 3-aminophenylboronic acid modified mesoporous silica and mannose. According to the mannose self-assembled nanoparticles provided by the invention, mesoporous silica modified by 3-aminophenylboronic acid is taken as a connecting unit and is generated with mannose, and the nano-micelles can be generated through self-assembly and are decomposed again under the acidic condition in cells and slowly release mannose. The nanoparticles can be applied to local skin application, and have application prospects in delaying skin aging. 本发明属于纳米颗粒技术领域，公开了一种甘露糖自组装纳米粒及其制备方法与应用，具体公开了一种甘露糖自组装纳米粒，所述甘露糖自组装纳米粒由3-氨基苯硼酸修饰的介孔二氧化硅与甘露糖自组装而成。本发明提供的甘露糖自组装纳米粒以3-氨基苯硼酸修饰的介孔二氧化硅为连接单元，与甘露糖生成，该可自组装生成纳米胶束，在细胞内酸性条件下重新分解且缓慢释放出甘露糖。该纳米粒能够用于皮肤局部涂抹，