Preparation process and application of stable benzoyl peroxide ointment

The invention provides a preparation process and application of stable benzoyl peroxide ointment, and the stable benzoyl peroxide ointment is prepared from the following raw material components in parts by weight: 0.5 to 1 part of active ingredients, 0.1 to 0.5 part of carbomer 980, 0.5 to 1 part of...

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Hauptverfasser: ZHANG ZHIYONG, PANG YUNLU, LIU YUANYUAN, CUI XU, CAI QINGXIU, YANG BITAO, ZHENG YANI, WANG YINGJUN, REN XINGCHI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a preparation process and application of stable benzoyl peroxide ointment, and the stable benzoyl peroxide ointment is prepared from the following raw material components in parts by weight: 0.5 to 1 part of active ingredients, 0.1 to 0.5 part of carbomer 980, 0.5 to 1 part of propylene glycol, 0.1 to 0.5 part of docusate sodium, 0.01 to 0.1 part of 1, 3-dihydroxymethyl-5, 5-dimethylhydantoin and 10 to 15 parts of water. The benzoyl peroxide-macrocyclic compound compound prepared by the invention is used as a main active component, so that the ultraviolet stability and thermal stability of the prepared ointment are improved, and the irritation to skin is reduced. And meanwhile, carbomer 980 and a benzoyl peroxide-macrocyclic compound are synergistically used, so that the water solubility of the compound is improved, the skin permeability of active ingredients is improved, and the antibacterial curative effect of the ointment is improved. 本发明提供了一种稳定的过氧化苯甲酰软膏的制备工艺及应用,其包含如下重量份的原料组分:活性成分0.5