Substituted pyrrolo [2, 3-d] pyrimidines, preparation thereof and therapeutic applications thereof

Substituted pyrrolo [2, 3-d] pyrimidines, preparation thereof and therapeutic applications thereof

Disclosed are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of using such compounds as LRRK2 inhibitors, as well as pharmaceutical compositions comprising such compounds. These compounds are useful in the t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MAKOWER JOSHUA, PETIT FLORIAN, BERNARDELLI PAOLO, DUBOIS LAURENT, DEPRETS STEPHANIE, TERRY CHRISTOPHER, BIANCIOTTO MICHELE
Format: Patent
Sprache:chi ; eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of using such compounds as LRRK2 inhibitors, as well as pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of neurodegenerative diseases, such as Parkinson's disease. # imgabs0 # 公开了式(I)的化合物或其药学上可接受的盐，其中R1和R2如本文所定义。还公开了使用此类化合物作为LRRK2抑制剂的方法，以及包含此类化合物的药物组合物。这些化合物可用于治疗神经变性疾病，诸如帕金森病。#imgabs0#