Novel compound and application thereof

The present invention provides compounds of general formula (I) or pharmaceutically acceptable prodrugs, salts and/or solvates thereof wherein LHS is a compound of formula (II). And wherein the star number (*) represents a connection point; these compounds exhibit antibacterial activity against gram-negative and gram-positive bacteria, in particular Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. Also provided are pharmaceutical compositions comprising these compounds, their therapeutic uses and methods of making the same. # imgabs0 # 本发明提供了通式(I)的化合物或其药学上可接受的前药、盐和/或溶剂化物，其中，LHS是式(II)的化合物。并且其中，星号(*)表示连接点；这些化合物表现出针对革兰氏阴性和革兰氏阳性菌，特别是金黄色葡萄球菌、大肠杆菌、肺炎克雷伯菌和鲍曼不动杆菌的抗菌活性。还提供了包含这些化合物的药物组合物、其治疗用途及其制造方法。#imgabs0#