Phenyl-sulfamoyl-benzoic acid derivatives as ERAP1 modulators

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, # imgabs0 # wherein: the group X-Y is-NHSO2-; z is a monocyclic or polycyclic cycloalkyl, or a monocyclic or polycyclic heterocycloalkyl, each optionally substituted by one or more groups selected from the group consisting of haloalkyl, alkyl, alkenyl, alkynyl and-(CR16R17) mR18 wherein m is 0 to 6; l is a direct bond or group (CR14R15) n, wherein n is 1 or 2; r1 is H, CN, Cl or F or alkyl; r2 is selected from COOH and tetrazolyl; r3 is selected from H, a halogenated group, an alkoxy group and an alkyl group; r4 is selected from H and a halogenated group; r5 is selected from H, alkyl, halogenated alkyl, SO2-alkyl, Cl, alkoxy, OH, CN, hydroxyalkyl, alkylthio, heteroaryl, cycloalkyl, heterocycloalkyl and halogenated alkoxy; r6 is H; r7 is selected from the group consisting of H, CN, halogenated alkyl, halogenated group, SO2-alkyl, SO2NR12R13, heteroaryl, CONR10R11 and alkyl, wherein the heteroary