Lactobacillus fermentum DPUL-268 with immunomodulatory function and application of lactobacillus fermentum DPUL-268

The invention discloses a lactobacillus fermentum DPUL-268 with an immunoregulation function and application thereof, and belongs to the technical field of microorganisms, an LPS-induced RAW264.7 in-vitro inflammatory cell model is established to verify the immunoregulation function of the lactobaci...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: XIANG LU, TUO YANFENG, SONG YINGLONG, MOU GUANGQING
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a lactobacillus fermentum DPUL-268 with an immunoregulation function and application thereof, and belongs to the technical field of microorganisms, an LPS-induced RAW264.7 in-vitro inflammatory cell model is established to verify the immunoregulation function of the lactobacillus fermentum DPUL-268, the lactobacillus fermentum DPUL-268 can significantly reduce generation of RAW264.7 cell nitric oxide caused by LPS stimulation, can relieve inflammatory factors iNOS, and can be used for preparing an anti-inflammatory agent. According to the lactobacillus fermentum DPUL-268 disclosed by the invention, the phagocytic activity of RAW264.7 cells is increased through the overexpression of IL-1beta and TNF-alpha, the lactobacillus fermentum DPUL-268 is a safe strain, and the lactobacillus fermentum DPUL-268 is capable of preventing low immunity of mice induced by cyclophosphamide to a certain extent through intragastric administration and has a very good application prospect. 本发明公开了一株具有免疫调节功能的