Lactobacillus fermentum DPUL-268 with immunomodulatory function and application of lactobacillus fermentum DPUL-268
The invention discloses a lactobacillus fermentum DPUL-268 with an immunoregulation function and application thereof, and belongs to the technical field of microorganisms, an LPS-induced RAW264.7 in-vitro inflammatory cell model is established to verify the immunoregulation function of the lactobaci...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a lactobacillus fermentum DPUL-268 with an immunoregulation function and application thereof, and belongs to the technical field of microorganisms, an LPS-induced RAW264.7 in-vitro inflammatory cell model is established to verify the immunoregulation function of the lactobacillus fermentum DPUL-268, the lactobacillus fermentum DPUL-268 can significantly reduce generation of RAW264.7 cell nitric oxide caused by LPS stimulation, can relieve inflammatory factors iNOS, and can be used for preparing an anti-inflammatory agent. According to the lactobacillus fermentum DPUL-268 disclosed by the invention, the phagocytic activity of RAW264.7 cells is increased through the overexpression of IL-1beta and TNF-alpha, the lactobacillus fermentum DPUL-268 is a safe strain, and the lactobacillus fermentum DPUL-268 is capable of preventing low immunity of mice induced by cyclophosphamide to a certain extent through intragastric administration and has a very good application prospect.
本发明公开了一株具有免疫调节功能的 |
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