Fully human monoclonal antibody for resisting novel coronavirus and application of fully human monoclonal antibody

The invention relates to a fully human monoclonal antibody for resisting novel coronavirus and application of the fully human monoclonal antibody, and belongs to the technical field of bioengineering. The fully human monoclonal antibody has a heavy chain variable region and a light chain variable re...

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Hauptverfasser: YAO ZHIFENG, GUO HAO, XIN HONGBO, LAN LINGNING, LIU SUJUN, YU ZHIXIANG, HU PING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a fully human monoclonal antibody for resisting novel coronavirus and application of the fully human monoclonal antibody, and belongs to the technical field of bioengineering. The fully human monoclonal antibody has a heavy chain variable region and a light chain variable region; the amino acid sequence of the heavy chain variable region is as shown in SEQ ID NO: 19; the amino acid sequence of the light chain variable region is as shown in SEQ ID NO: 20. The invention also provides a coding gene, an expression vector, application and a composition of the antibody. The binding molecule can prevent the novel coronavirus from infecting susceptible cells, is completely human-derived, and compared with other animal-derived (such as mouse-derived) novel coronavirus-resistant molecules, the binding molecule is low in immunogenicity, good in affinity, good in treatment effect, low in side effect and free of toxic and side effects. And meanwhile, the reliable effectiveness and safety also prov