Self-assembled nano anti-inflammatory drug as well as preparation method and application thereof

The invention discloses a self-assembled nano anti-inflammatory drug and a preparation method and application thereof.The self-assembled nano anti-inflammatory drug is composed of low-molecular heparin, a carboxyl-containing anti-inflammatory drug and an active oxygen scavenger, and the mass ratio of the low-molecular heparin to the carboxyl-containing anti-inflammatory drug ranges from 0.3: 1 to 40: 1. The mass ratio of the low molecular weight heparin to the active oxygen scavenger is 0.5: 1-8: 1, and the particle size of the nano anti-inflammatory drug is 60-360 nm. The self-assembled nano anti-inflammatory drug is intravenously injected or loaded in hydrogel to form composite hydrogel for vagina local delivery administration, and is targeted to the uterus and placenta decidua layer to achieve the purposes of resisting inflammation, resisting oxidative stress and inhibiting uterine contraction so as to prevent and treat premature delivery. The nano anti-inflammatory drug has the advantages of simple synthe