IRGM small-molecule inhibitor as well as screening method, application and binding site thereof

The invention provides an IRGM small-molecule inhibitor and a screening method, application and a binding site thereof, and belongs to the technical field of biological medicines.The screening method comprises the steps that the three-dimensional space structure of IRGM is predicted; wherein the ami...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG BO, LI RUI, TIAN LINLU, XU HONGWEI, PEI CHUNYING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides an IRGM small-molecule inhibitor and a screening method, application and a binding site thereof, and belongs to the technical field of biological medicines.The screening method comprises the steps that the three-dimensional space structure of IRGM is predicted; wherein the amino acid sequence of the IRGM is as shown in SEQ ID NO. 1; according to the three-dimensional space structure and the biological function of the IRGM, screening a binding site of an IRGM small-molecule inhibitor; according to the binding sites, compound virtual screening, artificial screening and melanoma cell proliferation experiment screening are sequentially carried out, and the IRGM small-molecule inhibitor is obtained. According to the invention, the IRGM small-molecule inhibitor with high specificity, high affinity and high inhibition can be accurately screened, an effective IRGM specific inhibitor is found, and help is provided for basic research of IRGM to clinical transformation. 本发明提供一种IRGM小分子抑制剂及其筛选方法、应用及