Application of XOR protein or coding gene thereof as target spot in preparation of medicine for preventing and/or treating vascular calcification

The invention provides application of XOR protein or a coding gene thereof as a target spot in preparation of a medicine for preventing and/or treating vascular calcification, and belongs to the technical field of prevention and treatment of vascular calcification. The XOR (xanthine oxidoreductase)...

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Bibliographische Detailangaben
Hauptverfasser:	AN WEIWEI, LI YANG, CAO CHUNMEI, QU YINGJIAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides application of XOR protein or a coding gene thereof as a target spot in preparation of a medicine for preventing and/or treating vascular calcification, and belongs to the technical field of prevention and treatment of vascular calcification. The XOR (xanthine oxidoreductase) protein or the coding gene thereof can be used as a target spot for preventing or treating vascular calcification diseases for the first time, the vascular calcification can be relieved by inhibiting XOR gene expression or inhibiting XOR protein activity for the first time, and the cell calcification can be inhibited by low expression of the XOR gene at the cellular level. In addition, the invention proposes that XOR affects vascular calcification by regulating and controlling HSPA1B for the first time. 本发明提供了XOR蛋白或其编码基因作为靶点在制备预防和/或治疗血管钙化药物中的应用，属于血管钙化防治技术领域。本发明首次提出XOR(黄嘌呤氧化还原酶)蛋白或其编码基因能够作为预防或治疗血管钙化疾病的靶点，本发明首次提出抑制XOR基因表达或抑制XOR蛋白活性能够减轻血管钙化，在细胞水平低表达XOR基因能够抑制细胞钙化。另外，本发明首次提出XOR通过调控HSPA1B影响血管钙化。