Anti-human CD70 antibody and application thereof

The invention discloses an anti-human CD70 antibody, a fusion protein and application thereof, the anti-human CD70 antibody comprises at least one immunoglobulin single variable domain (ISVD) combined with human CD70, the ISVD has three complementary determining regions of CDR1, CDR2 and CDR3, the CDR1 has an amino acid sequence as shown in SEQ ID NO: 13, the CDR2 has an amino acid sequence as shown in SEQ ID NO: 14, the ISVD has an amino acid sequence as shown in SEQ ID NO: 16, and the ISVD has an amino acid sequence as shown in SEQ ID NO: 16. The CDR3 has an amino acid sequence as shown in SEQ ID NO: 15. The anti-human CD70 antibody can be combined with a recombinant human CD70 antigen with high affinity, block the combination of the CD70 and a receptor CD27 of the CD70, induce the internalization of an antigen-antibody compound through the CD70 combined on the cell surface, and activate lymphocytes to kill tumor cells. 本发明公开了抗人CD70抗体、融合蛋白，及其应用,其中，该抗人CD70抗体包括至少一个结合人CD70的免疫球蛋白单一可变结构域(ISVD)，所述ISVD具有三个分别为CDR1、