Preparation method of ubiquitin ligase HUWE1 specific antagonist BI8626

The invention discloses a preparation method of a specific antagonist BI8626 of ubiquitin ligase HUWE1. The preparation method comprises the following steps: performing deprotection on a compound G to obtain a compound BI8626; the compound G is obtained by the preparation method of the intermediate G; according to the method, the raw material obtaining difficulty is reduced, purification is simple, the yield is high, the production cost is reduced, the final production steps are simple, and production and popularization are easy. 本发明公开了一种泛素连接酶HUWE1特异性拮抗剂BI8626的制备方法，包括下列步骤：化合物G脱保护得到化合物BI8626；所述化合物G通过所述中间体G的制备方法得到；本发明降低了原料获取的难度，其次纯化简单，收率高，从而使生产成本降低，最后生产步骤简单，易于生产与推广。