Purification preparation method of Vonoprazan fumarate

The invention belongs to the technical field of medicine synthesis, and particularly relates to a purification preparation method of Vonoprazan fumarate. The method comprises the following steps: S1, heating and dissolving a Vonoprazan free alkali crude product with methanol and water, dropwise adding phosphoric acid at a controlled temperature, adjusting the pH value to 3.0-4.0, and cooling and crystallizing to obtain a Vonoprazan phosphate wet product; s2, directly adding the wet Vonoprazan phosphate product into ethyl acetate and water, adjusting to be alkaline with potassium carbonate for liquid separation, adding activated carbon into an ethyl acetate layer for decoloration and filtration, concentrating to be dry, then adding methanol and fumaric acid, heating to form salt, and cooling and filtering to obtain Vonoprazan fumarate. The method has the advantages of simple operation steps, low cost, less amount of three wastes, environmental protection and high product purity, and is more suitable for indust