Novel method for preparing antibody-drug conjugates

The present invention relates to a novel method for preparing antibody-drug conjugates. A method for producing a compound represented by formula (C) wherein R1 represents an amino group protected by a protecting group, the method comprising a step of subjecting a compound represented by formula (B)...

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Bibliographische Detailangaben
Hauptverfasser:	TAKEDA TADAHIRO, SAKANISHI KOHEI, NOGUCHI SHIGERU, HITOSHI YOSHIO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a novel method for preparing antibody-drug conjugates. A method for producing a compound represented by formula (C) wherein R1 represents an amino group protected by a protecting group, the method comprising a step of subjecting a compound represented by formula (B) to intramolecular cyclization to convert the compound into the compound represented by formula (C) wherein R1 represents the same meaning as described above. # imgabs0 # 本发明涉及制备抗体-药物缀合物的新方法。式(C)表示的化合物的制备方法，其中R1表示被保护基团保护的氨基，所述方法包括使式(B)表示的化合物进行分子内环化以将该化合物转化为式(C)表示的化合物的步骤，其中R1表示与上述相同的含义。#imgabs0#