Expression promoter for keratinocyte fibronectin gene FLG

The invention provides an expression promoter of keratinocyte fibronectin gene FLG, the expression promoter is a selaginella tamariscina aqueous extract, the selaginella tamariscina aqueous extract is obtained by adopting water as an extraction solvent, and the selaginella tamariscina aqueous extract is extracted by a reflux method and concentrated under reduced pressure. The invention also relates to a preparation method of the expression promoter of keratinocyte fibropolyprotein gene FLG and an application of the expression promoter in an external preparation for skin. 本发明提供了一种角质形成细胞丝聚蛋白基因FLG的表达促进剂，其中，所述表达促进剂是卷柏水提物，所述卷柏水提物采用水作为提取溶剂，通过回流法萃取，减压浓缩后获得卷柏水提物。本发明还涉及角质形成细胞丝聚蛋白基因FLG的表达促进剂的制备方法及其在皮肤外用剂中的应用。