Method for producing renal interstitial precursor cells, erythropoietin-producing cell, and method for producing renin-producing cell

Method for producing renal interstitial precursor cells, erythropoietin-producing cell, and method for producing renin-producing cell

A method for producing renal interstitial precursor cells, said method comprising a step for culturing HOXC10-positive cells in a culture medium containing a GSK (Glycogen Synthase Kinase)-3 [beta] inhibitor, an SHH (Sonic Hedgehog) signal activator, and a TGF (Transforming Growth Factor) [beta] inh...

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Bibliographische Detailangaben
Hauptverfasser: OSAFUNE KENJI, TSUJIMOTO KEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A method for producing renal interstitial precursor cells, said method comprising a step for culturing HOXC10-positive cells in a culture medium containing a GSK (Glycogen Synthase Kinase)-3 [beta] inhibitor, an SHH (Sonic Hedgehog) signal activator, and a TGF (Transforming Growth Factor) [beta] inhibitor, preferably further containing IL (Interleukin)-1 [beta] and retinoic acid, and inducing the formation of renal interstitial precursor cells. 一种肾间质前体细胞的制造方法，所述制造方法包括：将HOXC10阳性细胞在包含GSK(糖原合成酶激酶)-3β抑制剂、SHH(音猬因子(Sonic Hedgehog))信号活化剂和TGF(转化生长因子(Transforming growth factor))β抑制剂、优选还包含IL(白介素(Interleukin))-1β和视黄酸的培养基中培养以诱导成肾间质前体细胞的工序。