Bifidobacterium bifidum capable of remarkably improving expression quantity of host BDNF and application of bifidobacterium bifidum

The invention discloses bifidobacterium bifidum capable of remarkably improving the expression quantity of host BDNF and application of the bifidobacterium bifidum, and belongs to the technical field of microorganisms. The bifidobacterium bifidum CCFM1359 provided by the invention can effectively im...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN WEI, WANG LINLIN, WANG GANG, ZHAO JIANXIN, ZHANG HAO, ZHU SHENGNAN, CUI SHUMAO, YU QIANGQING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses bifidobacterium bifidum capable of remarkably improving the expression quantity of host BDNF and application of the bifidobacterium bifidum, and belongs to the technical field of microorganisms. The bifidobacterium bifidum CCFM1359 provided by the invention can effectively improve the levels of BDNF and a specific receptor TrkB thereof in the colon of a mouse, and also can increase the number of intestinal glial cells, improve the content of excitatory neurotransmitter Ach in the colon, reduce the content of inhibitory neurotransmitter NO and repair an enteric nervous system. And the strain can down-regulate the gene expression levels of TLR2 and TNF-alpha, up-regulate the gene expression level of IL-10, reduce the inflammation level in colon and regulate intestinal motility. Therefore, a more personalized treatment scheme can be adopted for patients (including but not limited to intestinal dyskinesia) with intestinal nerve damage in the future, and the method has a very considerable a