VEGF and ANG-2 bispecific antibody and application thereof

The invention provides a VEGF and ANG-2 bispecific antibody and application thereof, the bispecific antibody comprises: a first binding region, the first binding region comprises a single-chain antibody, and the single-chain antibody has ANG-2 binding activity; and the second binding region comprise...

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Bibliographische Detailangaben
Hauptverfasser: WEI XILING, QIU YUXIN, DENG FEIYAN, SHANG WEI, QIN SUOFU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a VEGF and ANG-2 bispecific antibody and application thereof, the bispecific antibody comprises: a first binding region, the first binding region comprises a single-chain antibody, and the single-chain antibody has ANG-2 binding activity; and the second binding region comprises a VEGF (vascular endothelial growth factor) receptor fragment. According to the embodiment of the invention, the bispecific antibody has good binding activity with VEGF and ANG-2, and can effectively block binding of VEGF and ANG-2 with their respective receptors, thereby effectively treating or preventing related diseases caused by angiogenesis. 本发明提出了一种VEGF和ANG-2双特异性抗体及其应用,该双抗包括:第一结合区,所述第一结合区包含单链抗体,所述单链抗体具有ANG-2结合活性;第二结合区,所述第二结合区包括VEGF受体片段。根据本发明实施例的双特异性抗体与VEGF和ANG-2具有较好的结合活性,能够有效阻断VEGF和ANG-2与其各自受体的结合,从而有效治疗或预防血管生成引起的相关疾病。