Magnetic resonance chemical exchange saturation displacement imaging nanoprobe responding to tumor microenvironment and application of magnetic resonance chemical exchange saturation displacement imaging nanoprobe

The invention discloses a magnetic resonance chemical exchange saturation displacement imaging nanoprobe responding to a tumor microenvironment and application of the magnetic resonance chemical exchange saturation displacement imaging nanoprobe. The chemical exchange saturation displacement imaging probe disclosed by the invention is prepared by coordinating lanthanide metal ion salt with a substrate through a hydrothermal synthesis method; the lanthanide metal ion salt comprises one or more of europium chloride hexahydrate, europium chloride and holmium chloride; the substrate has a guanidyl group and an amino group. According to the present invention, by optimizing the substrate, the metal ions and the reaction conditions, the prepared probe can stay in the tumor for a long time, such that the pH value can be easily detected, and the interference caused by metabolism can be avoided; meanwhile, the CEST is used for imaging the imaging probe, so that malignant degrees of different subtypes of BCC can be iden