Application of benzamide derivative to improvement of cognitive impairment

The invention discloses an application of a benzamide derivative or a pharmaceutically acceptable salt thereof in preparation of a medicine for improving cognitive impairment. The benzamide derivative has a structural formula as shown in a formula I which is described in the specification. The benza...

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Bibliographische Detailangaben
Hauptverfasser:	YU DONGCHUAN, WANG WAN, MU RONGHAO, YANG YANYAN, LIU QI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses an application of a benzamide derivative or a pharmaceutically acceptable salt thereof in preparation of a medicine for improving cognitive impairment. The benzamide derivative has a structural formula as shown in a formula I which is described in the specification. The benzamide derivative with the structural formula as shown in the formula I can improve mouse cognitive impairment induced by Abeta1-42 and APP/PS1 mouse cognitive impairment without affecting spontaneous activity of mice. # imgabs0 # 本发明公开了一种苯甲酰胺衍生物或其药学上可接受的盐在制备用于改善认知功能障碍的药品中的用途，该苯甲酰胺衍生物具有式I所示的结构式。本发明的具有式I所示的结构式的苯甲酰胺衍生物能够改善Aβ1-42诱导的小鼠认知障碍和APP/PS1小鼠认知障碍，而不影响小鼠自发活动。#imgabs0#