Drug-loaded embolism microsphere and preparation method thereof

The invention discloses a drug-loaded embolism microsphere and a preparation method thereof, and belongs to the technical field of polymer biological medicines. The preparation method comprises the following steps: preparing a polyvinyl alcohol aqueous solution with the mass fraction of 10-20%, heating, dissolving, adding a catalyst, a cross-linking agent and a pH regulator, carrying out a magnetic stirring reaction, freeze-drying to obtain a polyvinyl alcohol macromonomer, mixing the polyvinyl alcohol macromonomer solution and an oxidation initiator solution according to a mixing molar ratio of 1-10, dissolving a dispersing agent in a continuous phase, and carrying out a reaction under the protection of an inert gas to obtain a polyvinyl alcohol solution; suspending the water phase in an organic oil phase, closing nitrogen, heating in an oil bath to 50-60 DEG C, adding a reduction initiator, carrying out a cross-linking reaction, washing with purified water for 2-3 times, and drying to obtain the drug-loadin