Expression promoter for keratinocyte fibronectin gene FLG

The invention provides an expression promoter of keratinocyte filament polyprotein gene FLG, the expression promoter is a selaginella tamariscina alcohol extract, and the selaginella tamariscina alcohol extract is obtained by adopting water as an extraction solvent and carrying out reflux extraction and vacuum concentration on the selaginella tamariscina alcohol extract to obtain the selaginella tamariscina alcohol extract. The invention also relates to a preparation method of the expression promoter of keratinocyte fibropolyprotein gene FLG and an application of the expression promoter in an external preparation for skin. 本发明提供了一种角质形成细胞丝聚蛋白基因FLG的表达促进剂，其中，所述表达促进剂是卷柏醇提物，所述卷柏醇提物采用水作为提取溶剂，通过回流法萃取，减压浓缩后获得卷柏醇提物。本发明还涉及角质形成细胞丝聚蛋白基因FLG的表达促进剂的制备方法及其在皮肤外用剂中的应用。