Expression promoter of longevity gene SIRT1

The invention provides an expression promoter of a keratinocyte longevity gene SIRT1, and the expression promoter is amentoflavone. Preferably, the use concentration of the amentoflavone is at least 0.000625 mg/ml. The invention also relates to an application of amentoflavone in preparing a skin external preparation with the effect of promoting the expression of the keratinocyte longevity gene SIRT1. Preferably, the content of the amentoflavone in the external preparation for the skin is 0.00001 to 10 weight percent. 本发明提供了一种角质形成细胞长寿基因SIRT1的表达促进剂，其中，所述表达促进剂是穗花杉双黄酮。优选地，穗花杉双黄酮的使用浓度至少为0.000625mg/ml。本发明还涉及穗花杉双黄酮在制备具有促进角质形成细胞长寿基因SIRT1的表达功效的皮肤外用剂中的应用。优选地，所述穗花杉双黄酮在皮肤外用剂中的含量为0.00001-10重量％。