N-(hydroxyalkyl (hetero) aryl) tetrahydrofurancarboxamide analogs as sodium channel modulators

Compounds of Formula (I) and pharmaceutically acceptable salts thereof useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or the pharmaceutically acceptable salts, and methods of using the compounds, the pharmaceutically accep...

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Hauptverfasser:	PONTILLO JOSEPH, HADIDA RUAH SARA SABINA, SCARLATT SCOTT, CARVALHO MEIRELES LUIS MIGUEL, HURLEY DENNIS JAMES, PANDE, JAYESH, L, SOUSA BENJAMIN A, DURRANT STEVEN JOHN, BULLIN ROBERT, MI, JACQUES, R, STAMOS, DEAN, VIRANI ANISA NIZARALI, THOMSON STEPHEN ANDREW, ZHOU JINGLAN, WEY CHRISTIAN, KUENZLE ANDREAS, AHMAD NAVEED M, NIGTEL ROBERT M, ECHEBARRIA JADI GORKA, MILLER MARK THOMAS, BAIK, ERIC, M, TSADIK EVGENIJ IGOREVICH, O 'DONNELL MICHAEL EDWARD, NEUBERT, TIMOTHY, D, NORTH KATHARINE, DODD JAMES, SCHMIDT YVONNE, GALLAN BENJAMIN, SHAW, DAVID, M
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of Formula (I) and pharmaceutically acceptable salts thereof useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or the pharmaceutically acceptable salts, and methods of using the compounds, the pharmaceutically acceptable salts, and the pharmaceutical compositions in the treatment of various conditions, including pain. # imgabs0 # 提供了可用作钠通道抑制剂的式(I)化合物和其药学上可接受的盐。还提供了包括所述化合物或所述药学上可接受的盐的药物组合物以及使用所述化合物、所述药学上可接受的盐和所述药物组合物治疗各种病症，包含疼痛的方法。#imgabs0#