Solid dosage forms and dosing regimens comprising (2r, 3s, 4s, 5r)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide
Provided are a solid dispersion of (2R, 3S, 4S, 5R)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide (Compound 1), as defined herein, or a pharmaceutically acceptable salt thereof, and a tablet for the treatment of pai...
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| creator | HARRER, THOMAS, L JIANG LICONG PETERSEN, MICHAEL, C BENITO GALLO PABLO CIRINCIONE BRENDA DINEHART KARL RICHARD COLLIER, DANIEL, J KARKARE RADHIKA MCCARTY, KEVIN, L RUPVANI RICCARDO STAROPNE JOHN F CHU CYNTHIA DELF, PETER, K., H MEZLER, CHRISTOPHER, P JONES, JEFFREY, B MILLER, JAMES, M |
| description | Provided are a solid dispersion of (2R, 3S, 4S, 5R)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide (Compound 1), as defined herein, or a pharmaceutically acceptable salt thereof, and a tablet for the treatment of pain containing the solid dispersion. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
提供了一种如本文所定义的(2R,3S,4S,5R)-4-[[3-(3,4-二氟-2-甲氧基-苯基)-4,5-二甲基-5-(三氟甲基)四氢呋喃-2-羰基]氨基]吡啶-2-甲酰胺(化合物1)或其药学上可接受的盐的固体分散体，以及含有所述固体分散体的用于治疗疼痛的片剂。本文还公开了在治疗疼痛的方法中使用的化合物1或其药学上可接受的盐。 |
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提供了一种如本文所定义的(2R,3S,4S,5R)-4-[[3-(3,4-二氟-2-甲氧基-苯基)-4,5-二甲基-5-(三氟甲基)四氢呋喃-2-羰基]氨基]吡啶-2-甲酰胺(化合物1)或其药学上可接受的盐的固体分散体，以及含有所述固体分散体的用于治疗疼痛的片剂。本文还公开了在治疗疼痛的方法中使用的化合物1或其药学上可接受的盐。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240329&DB=EPODOC&CC=CN&NR=117794537A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240329&DB=EPODOC&CC=CN&NR=117794537A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HARRER, THOMAS, L</creatorcontrib><creatorcontrib>JIANG LICONG</creatorcontrib><creatorcontrib>PETERSEN, MICHAEL, C</creatorcontrib><creatorcontrib>BENITO GALLO PABLO</creatorcontrib><creatorcontrib>CIRINCIONE BRENDA</creatorcontrib><creatorcontrib>DINEHART KARL RICHARD</creatorcontrib><creatorcontrib>COLLIER, DANIEL, J</creatorcontrib><creatorcontrib>KARKARE RADHIKA</creatorcontrib><creatorcontrib>MCCARTY, KEVIN, L</creatorcontrib><creatorcontrib>RUPVANI RICCARDO</creatorcontrib><creatorcontrib>STAROPNE JOHN F</creatorcontrib><creatorcontrib>CHU CYNTHIA</creatorcontrib><creatorcontrib>DELF, PETER, K., H</creatorcontrib><creatorcontrib>MEZLER, CHRISTOPHER, P</creatorcontrib><creatorcontrib>JONES, JEFFREY, B</creatorcontrib><creatorcontrib>MILLER, JAMES, M</creatorcontrib><title>Solid dosage forms and dosing regimens comprising (2r, 3s, 4s, 5r)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide</title><description>Provided are a solid dispersion of (2R, 3S, 4S, 5R)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide (Compound 1), as defined herein, or a pharmaceutically acceptable salt thereof, and a tablet for the treatment of pain containing the solid dispersion. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
提供了一种如本文所定义的(2R,3S,4S,5R)-4-[[3-(3,4-二氟-2-甲氧基-苯基)-4,5-二甲基-5-(三氟甲基)四氢呋喃-2-羰基]氨基]吡啶-2-甲酰胺(化合物1)或其药学上可接受的盐的固体分散体，以及含有所述固体分散体的用于治疗疼痛的片剂。本文还公开了在治疗疼痛的方法中使用的化合物1或其药学上可接受的盐。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLFqwzAQhr10KGnf4bo5kBsS2ZiOIbR06tJuIQTFOtsCWSdOCkQP2PeqmqZ7h-OH7__-u6--PthZA4ajHgkGljmC9ldg_QhCo53JR-h5DmKvrN7IClRcQVOulSU2uN8rrFUhaOzgziyMG5wpTXzJGCby2RWt2KX_wdlhi3WSm_yLlpAoiZ6yER7Oon350Ws5cVkfQM_W8wFCFmusp7_uUrihh-pu0C7S4y0X1dPry-fuDSnwkWLQPXlKx937et11z02ruq36j_MN2Alejw</recordid><startdate>20240329</startdate><enddate>20240329</enddate><creator>HARRER, THOMAS, L</creator><creator>JIANG LICONG</creator><creator>PETERSEN, MICHAEL, C</creator><creator>BENITO GALLO PABLO</creator><creator>CIRINCIONE BRENDA</creator><creator>DINEHART KARL RICHARD</creator><creator>COLLIER, DANIEL, J</creator><creator>KARKARE RADHIKA</creator><creator>MCCARTY, KEVIN, L</creator><creator>RUPVANI RICCARDO</creator><creator>STAROPNE JOHN F</creator><creator>CHU CYNTHIA</creator><creator>DELF, PETER, K., H</creator><creator>MEZLER, CHRISTOPHER, P</creator><creator>JONES, JEFFREY, B</creator><creator>MILLER, JAMES, M</creator><scope>EVB</scope></search><sort><creationdate>20240329</creationdate><title>Solid dosage forms and dosing regimens comprising (2r, 3s, 4s, 5r)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide</title><author>HARRER, THOMAS, L ; JIANG LICONG ; PETERSEN, MICHAEL, C ; BENITO GALLO PABLO ; CIRINCIONE BRENDA ; DINEHART KARL RICHARD ; COLLIER, DANIEL, J ; KARKARE RADHIKA ; MCCARTY, KEVIN, L ; RUPVANI RICCARDO ; STAROPNE JOHN F ; CHU CYNTHIA ; DELF, PETER, K., H ; MEZLER, CHRISTOPHER, P ; JONES, JEFFREY, B ; MILLER, JAMES, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117794537A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HARRER, THOMAS, L</creatorcontrib><creatorcontrib>JIANG LICONG</creatorcontrib><creatorcontrib>PETERSEN, MICHAEL, C</creatorcontrib><creatorcontrib>BENITO GALLO PABLO</creatorcontrib><creatorcontrib>CIRINCIONE BRENDA</creatorcontrib><creatorcontrib>DINEHART KARL RICHARD</creatorcontrib><creatorcontrib>COLLIER, DANIEL, J</creatorcontrib><creatorcontrib>KARKARE RADHIKA</creatorcontrib><creatorcontrib>MCCARTY, KEVIN, L</creatorcontrib><creatorcontrib>RUPVANI RICCARDO</creatorcontrib><creatorcontrib>STAROPNE JOHN F</creatorcontrib><creatorcontrib>CHU CYNTHIA</creatorcontrib><creatorcontrib>DELF, PETER, K., H</creatorcontrib><creatorcontrib>MEZLER, CHRISTOPHER, P</creatorcontrib><creatorcontrib>JONES, JEFFREY, B</creatorcontrib><creatorcontrib>MILLER, JAMES, M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HARRER, THOMAS, L</au><au>JIANG LICONG</au><au>PETERSEN, MICHAEL, C</au><au>BENITO GALLO PABLO</au><au>CIRINCIONE BRENDA</au><au>DINEHART KARL RICHARD</au><au>COLLIER, DANIEL, J</au><au>KARKARE RADHIKA</au><au>MCCARTY, KEVIN, L</au><au>RUPVANI RICCARDO</au><au>STAROPNE JOHN F</au><au>CHU CYNTHIA</au><au>DELF, PETER, K., H</au><au>MEZLER, CHRISTOPHER, P</au><au>JONES, JEFFREY, B</au><au>MILLER, JAMES, M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Solid dosage forms and dosing regimens comprising (2r, 3s, 4s, 5r)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide</title><date>2024-03-29</date><risdate>2024</risdate><abstract>Provided are a solid dispersion of (2R, 3S, 4S, 5R)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide (Compound 1), as defined herein, or a pharmaceutically acceptable salt thereof, and a tablet for the treatment of pain containing the solid dispersion. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
提供了一种如本文所定义的(2R,3S,4S,5R)-4-[[3-(3,4-二氟-2-甲氧基-苯基)-4,5-二甲基-5-(三氟甲基)四氢呋喃-2-羰基]氨基]吡啶-2-甲酰胺(化合物1)或其药学上可接受的盐的固体分散体，以及含有所述固体分散体的用于治疗疼痛的片剂。本文还公开了在治疗疼痛的方法中使用的化合物1或其药学上可接受的盐。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Solid dosage forms and dosing regimens comprising (2r, 3s, 4s, 5r)-4-[[3-(3, 4-difluoro-2-methoxy-phenyl)-4, 5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl] amino] pyridine-2-carboxamide |
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