Attenuated microorganisms for treatment of infection

一种沙门氏菌属的微生物具有一个破坏、一种器官基因表达的减毒突变和一个营养缺陷型突变，所述器官基因定位于Spi2致病性岛中。该微生物因而具有一个有助于避免该微生物的反应性而保持该微生物激发免疫应答有效性的双重突变。 The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrop...

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Bibliographische Detailangaben
Hauptverfasser:	D.W. HOLDE, G. GOUGAN, J.D. SANTANGELO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	一种沙门氏菌属的微生物具有一个破坏、一种器官基因表达的减毒突变和一个营养缺陷型突变，所述器官基因定位于Spi2致病性岛中。该微生物因而具有一个有助于避免该微生物的反应性而保持该微生物激发免疫应答有效性的双重突变。 The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.