Preparation method for synthesizing empagliflozin intermediate through continuous reaction

The invention discloses a preparation method for synthesizing an empagliflozin intermediate through continuous reaction, relates to the field of medicinal chemistry, and solves the problems of low yield and unstable quality of an obtained empagliflozin product caused by tedious synthesis process route and harsh reaction conditions of an empagliflozin preparation method in the prior art. The method for synthesizing the empagliflozin drug intermediate through the Grignard reaction of the raw materials in the coil reactor in a continuous flow mode is simple in process, mild in reaction condition, high in reaction speed, few in side reaction, high in heat and mass transfer efficiency, high in reaction selectivity and convenient in post-treatment, the obtained product is high in purity and high in yield, and the method is suitable for industrial production. The synthesis method is high in safety and environmentally friendly, effectively reduces the production cost, and has a wide application prospect in industrial