Prodrugs specifically activated by senescence-related beta-galactosidase

The invention discloses a prodrug specifically activated by aging-related beta-galactosidase. The structure of the prodrug is shown as a formula I. The invention further discloses a preparation method of the prodrug. Under the activation of beta-galactosidase, the gemcitabine sustained-release table...

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Bibliographische Detailangaben
Hauptverfasser:	LI XINMING, GUO YUAN, MAO FEI, SONG YIHE, LI JIAN, LI XIAOKANG, SHI DONGLEI, YOU HAOLAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ADHESIVES CHEMISTRY DERIVATIVES THEREOF DYES HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PAINTS PHYSICS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS TESTING
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Beschreibung
Zusammenfassung:	The invention discloses a prodrug specifically activated by aging-related beta-galactosidase. The structure of the prodrug is shown as a formula I. The invention further discloses a preparation method of the prodrug. Under the activation of beta-galactosidase, the gemcitabine sustained-release tablet can quickly release the active drug gemcitabine, has high release efficiency, can remove senescence cells in kidney of renal failure mice, improves renal functions and alleviates renal failure, and is used for treating senescence and senescence-related diseases. # imgabs0 # 本发明公开了一种衰老相关β-半乳糖苷酶特异性激活的前药，结构如式I所示。在β-半乳糖苷酶激活下，能够迅速释放原药吉西他滨，且释放效率高，能够清除肾衰小鼠肾脏中的衰老细胞，提高肾脏功能缓解肾衰竭，用于衰老及衰老相关疾病的治疗。#imgabs0#