Abamectin derivative and synthesis method thereof

The invention relates to the field of pesticides, in particular to an abamectin derivative and a synthesis method thereof. The synthesis method provided by the invention comprises the following steps: carrying out substitution reaction on abamectin and a silane protective agent in the presence of a first organic solvent by taking first organic alkali as a catalyst to obtain an intermediate I; in a second organic solvent, under the action of a pro-oxidant, carrying out oxidation reaction on the intermediate I and an oxidant by taking a second organic alkali as a catalyst, and washing and layering to obtain an intermediate II; under the action of a reaction accelerant and organic acid, the intermediate II, a methanol solution containing R-NH2 and a boron reducing agent are subjected to ammoniation and reduction reaction, and the abamectin derivative is obtained. According to the synthesis method provided by the invention, the reaction steps are reduced, the reaction process is optimized, the equipment investmen