Sesquiterpene trimer in artemisia sieversiana, pharmaceutical composition of sesquiterpene trimer, preparation method of sesquiterpene trimer and application of sesquiterpene trimer

The invention provides a sesquiterpene trimer in artemisia sieversiana as well as a pharmaceutical composition, a preparation method and application of the sesquiterpene trimer, and belongs to the technical field of medicines. The invention provides eight novel sesquiterpene trimers shown as a structural formula (I), Artemsiverolactones A-H (1-8) has obvious cytotoxic activity on human hepatic stellate cells (HSC-LX2), can form a pharmaceutical composition with a pharmaceutically acceptable carrier or an excipient, and can be used for preparing anti-hepatic fibrosis drugs. 本发明提供一种大籽蒿中倍半萜三聚体及其药物组合物与其制备方法和应用，属于药物技术领域。本发明提供结构式(I)所示8个新的倍半萜三聚体，Artemsieverolactones A-H(1-8)对人肝星状细胞(HSC-LX2)具有明显的细胞毒活性，能够与可药用载体或赋型剂组成药物组合物，能够用于制备抗肝纤维化药物。