Synthesis method of 2-furan ethyl propionate

The invention discloses a synthesis method of ethyl 2-furan propionate, and belongs to the technical field of synthesis of spices and medical intermediates. The preparation method comprises the following steps: reacting furfuryl alcohol with methylsulfonyl chloride to obtain a methanesulfonate intermediate, and then carrying out bromination reaction on the methanesulfonate intermediate to obtain 2-bromomethyl furan; under the action of strong base, 2-bromomethyl furan and ethyl acetate react to obtain the product 2-furan ethyl propionate. The synthesis method of ethyl 2-furan propionate provided by the invention has the advantages of cheap and economic reagents, mild reaction conditions, safe reaction process, high reaction yield (up to 94%) and high product purity (up to 99%), and is suitable for industrial production. 本发明公开了一种2-呋喃丙酸乙酯的合成方法，属于香料及医药中间体合成技术领域。本发明将糠醇和甲磺酰氯反应得到甲磺酸酯中间体，然后甲磺酸酯中间体进行溴代反应得到2-溴甲基呋喃；在强碱作用下，2-溴甲基呋喃和乙酸乙酯反应得到产物2-呋喃丙酸乙酯。本发明提供的2-呋喃丙酸乙酯的合成方法所用试剂廉价经济、反应条件温和、反应过程安全、反应收率高（可达94%）和产品纯度高（可达99%），适于工