Double-enzyme active vanadium-doped carbon dot nano vaccine vector capable of reversing tumor immunosuppression microenvironment

The invention discloses a vanadium-doped carbon dot nano vaccine carrier capable of reversing the double-enzyme activity of oxide enzyme and peroxidase in a tumor immunosuppression microenvironment. The vanadium-doped carbon dot nano vaccine carrier is prepared through a one-step solvothermal method...

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Hauptverfasser: NIE RENHAO, JIA QINGYAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a vanadium-doped carbon dot nano vaccine carrier capable of reversing the double-enzyme activity of oxide enzyme and peroxidase in a tumor immunosuppression microenvironment. The vanadium-doped carbon dot nano vaccine carrier is prepared through a one-step solvothermal method by taking quercetin, catechol, dihydroxy benzoic acid and the like as carbon sources, thioacetamide, urea, ammonia water and the like as nitrogen sources, ammonium metavanadate, vanadyl oxalate, vanadyl acetylacetonate and the like as vanadium sources and ethanol, ethylene glycol, deionized water and the like as solvents. The vanadium-doped carbon dot nano vaccine vector has double enzyme activity of oxygenase and peroxidase based on O2 and H2O2, multiple types of active oxygen are generated through parallel catalytic reaction to destroy extracellular matrix in a tumor microenvironment to reverse immunosuppression of the tumor microenvironment, and meanwhile, tumor cell immunogenicity death is induced to sensitize