Novel ipratropium bromide crystal and preparation method thereof
The invention belongs to the technical field of crystal form drug molecules, and particularly relates to a novel ipratropium bromide crystal and a preparation method thereof. According to the novel ipratropium bromide crystal provided by the invention, Cu-K alpha radiation is adopted, and an X-ray d...
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| creator | SUN LIJIA LIU HONGJIANG |
| description | The invention belongs to the technical field of crystal form drug molecules, and particularly relates to a novel ipratropium bromide crystal and a preparation method thereof. According to the novel ipratropium bromide crystal provided by the invention, Cu-K alpha radiation is adopted, and an X-ray diffraction spectrum represented by 2 theta has diffraction peaks at the positions of 8.76 +/-0.2 degrees, 10.26 +/-0.2 degrees, 12.68 +/-0.2 degrees, 13.75 +/-0.2 degrees, 14.08 +/-0.2 degrees, 15.23 +/-0.2 degrees, 15.59 +/-0.2 degrees, 17.21 +/-0.2 degrees, 18.40 +/-0.2 degrees, 20.30 +/-0.2 degrees, 22.43 +/-0.2 degrees, 25.11 +/-0.2 degrees, 27.37 +/-0.2 degrees and 29.04 +/-0.2 degrees; the new crystal of ipratropium bromide provided by the invention has excellent properties, excellent stability and solubility and lower moisture absorption weight gain, and provides a high-quality raw material choice for preparation production of ipratropium bromide.
本发明属于晶型药物分子技术领域，具体涉及一种异丙托溴铵新晶体及其制备方法。本发明提供的异丙托溴铵新晶体，使用Cu-Kα辐射 |
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本发明属于晶型药物分子技术领域，具体涉及一种异丙托溴铵新晶体及其制备方法。本发明提供的异丙托溴铵新晶体，使用Cu-Kα辐射</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240326&DB=EPODOC&CC=CN&NR=117756798A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240326&DB=EPODOC&CC=CN&NR=117756798A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUN LIJIA</creatorcontrib><creatorcontrib>LIU HONGJIANG</creatorcontrib><title>Novel ipratropium bromide crystal and preparation method thereof</title><description>The invention belongs to the technical field of crystal form drug molecules, and particularly relates to a novel ipratropium bromide crystal and a preparation method thereof. According to the novel ipratropium bromide crystal provided by the invention, Cu-K alpha radiation is adopted, and an X-ray diffraction spectrum represented by 2 theta has diffraction peaks at the positions of 8.76 +/-0.2 degrees, 10.26 +/-0.2 degrees, 12.68 +/-0.2 degrees, 13.75 +/-0.2 degrees, 14.08 +/-0.2 degrees, 15.23 +/-0.2 degrees, 15.59 +/-0.2 degrees, 17.21 +/-0.2 degrees, 18.40 +/-0.2 degrees, 20.30 +/-0.2 degrees, 22.43 +/-0.2 degrees, 25.11 +/-0.2 degrees, 27.37 +/-0.2 degrees and 29.04 +/-0.2 degrees; the new crystal of ipratropium bromide provided by the invention has excellent properties, excellent stability and solubility and lower moisture absorption weight gain, and provides a high-quality raw material choice for preparation production of ipratropium bromide.
本发明属于晶型药物分子技术领域，具体涉及一种异丙托溴铵新晶体及其制备方法。本发明提供的异丙托溴铵新晶体，使用Cu-Kα辐射</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDwyy9LzVHILChKLCnKL8gszVVIKsrPzUxJVUguqiwuScxRSMxLUSgoSi1IBCrJzM9TyE0tychPUSjJSC1KzU_jYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhubmpmbmlhaOxsSoAQAfGTIX</recordid><startdate>20240326</startdate><enddate>20240326</enddate><creator>SUN LIJIA</creator><creator>LIU HONGJIANG</creator><scope>EVB</scope></search><sort><creationdate>20240326</creationdate><title>Novel ipratropium bromide crystal and preparation method thereof</title><author>SUN LIJIA ; LIU HONGJIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117756798A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SUN LIJIA</creatorcontrib><creatorcontrib>LIU HONGJIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUN LIJIA</au><au>LIU HONGJIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel ipratropium bromide crystal and preparation method thereof</title><date>2024-03-26</date><risdate>2024</risdate><abstract>The invention belongs to the technical field of crystal form drug molecules, and particularly relates to a novel ipratropium bromide crystal and a preparation method thereof. According to the novel ipratropium bromide crystal provided by the invention, Cu-K alpha radiation is adopted, and an X-ray diffraction spectrum represented by 2 theta has diffraction peaks at the positions of 8.76 +/-0.2 degrees, 10.26 +/-0.2 degrees, 12.68 +/-0.2 degrees, 13.75 +/-0.2 degrees, 14.08 +/-0.2 degrees, 15.23 +/-0.2 degrees, 15.59 +/-0.2 degrees, 17.21 +/-0.2 degrees, 18.40 +/-0.2 degrees, 20.30 +/-0.2 degrees, 22.43 +/-0.2 degrees, 25.11 +/-0.2 degrees, 27.37 +/-0.2 degrees and 29.04 +/-0.2 degrees; the new crystal of ipratropium bromide provided by the invention has excellent properties, excellent stability and solubility and lower moisture absorption weight gain, and provides a high-quality raw material choice for preparation production of ipratropium bromide.
本发明属于晶型药物分子技术领域，具体涉及一种异丙托溴铵新晶体及其制备方法。本发明提供的异丙托溴铵新晶体，使用Cu-Kα辐射</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Novel ipratropium bromide crystal and preparation method thereof |
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