Modified collagen barrier membrane and preparation method thereof

The invention belongs to the technical field of biological material preparation, and particularly relates to a modified collagen barrier membrane and a preparation method thereof. The preparation method provided by the invention comprises the following steps: dissolving type I collagen and poly (L-lactide-caprolactone) in a volatile polar solvent to obtain a membrane casting solution; casting the membrane casting solution into a mold to form a membrane, so as to obtain a cross-linked membrane; and immersing the reverse side of the cross-linked membrane in a mineralizing solution for mineralization to obtain the collagen barrier membrane, the mineralizing liquid comprises Ca < 2 + >, polyaspartic acid and HPO4 < 2->. The modified collagen barrier membrane obtained by the preparation method provided by the invention takes type I collagen and poly (L-lactide-caprolactone) as raw materials, so that the cost is reduced, the mechanical property is better, and a stable proliferation space and enough proliferation ti