Formulations of dengue virus vaccine compositions

The present invention relates to formulations of a dengue virus vaccine comprising at least one live attenuated dengue virus or live attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a diol or sugar alcohol, optionally an alkali metal or alkaline earth metal salt and an amin...

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Hauptverfasser: JONES MATTHEW, STANBRO JUSTIN, BHAMBHANI, ARVIND, PIXLEY HEIDI JOANNE, ISOPI LYNNE ANN, MARTIN SHERRIE-ANN P, RYAN MICHAEL S, BLUE JEFFREY THOMAS, GREEN-TREXLER ERIN J
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to formulations of a dengue virus vaccine comprising at least one live attenuated dengue virus or live attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a diol or sugar alcohol, optionally an alkali metal or alkaline earth metal salt and an amino acid; and a dengue virus vaccine comprising at least one live attenuated dengue virus or live attenuated chimeric flavivirus, a buffer, at least 150 mg/ml of a sugar, a carrier and optionally an alkali metal or alkaline earth metal salt and an amino acid. 本发明涉及登革病毒疫苗的制剂,其包含至少一种活减毒登革病毒或活减毒嵌合黄病毒、缓冲剂、糖、纤维素衍生物、二醇或糖醇、任选地碱金属或碱土金属盐和氨基酸;和登革病毒疫苗的制剂,其包含至少一种活减毒登革病毒或活减毒嵌合黄病毒、缓冲剂、至少150mg/ml的糖、载体以及任选地碱金属或碱土金属盐和氨基酸。