Application of hypoxia-induced astrocyte exosome in treatment of retinal diseases

The invention discloses an application of an anoxia-induced astrocyte exosome in treatment of retinal diseases. Experiments show that compared with normal astrocyte exosomes, the astrocyte exosome subjected to hypoxia induction for 24 hours can remarkably relieve the severity of retinal diseases, inhibit death of retinal ganglion cells (RGCs) and increase the survival rate of the retinal ganglion cells, and therefore the astrocyte exosome subjected to hypoxia induction for 24 hours can be used for treating retinal diseases. The compound can be used for developing drugs for treating retinal diseases, including diabetic retinopathy, retinal vascular occlusion, premature infant retinopathy, glaucoma and other diseases which finally cause retinal ganglion cell death. 本发明公开了一种缺氧诱导的星形胶质细胞外泌体在治疗视网膜疾病中的应用。本发明通过实验发现，缺氧诱导24小时的星形胶质细胞外泌体相对于正常的星形胶质细胞外泌体，可以显著减轻视网膜疾病的严重程度，抑制视网膜神经节细胞(RGCs)的死亡，增加视网膜神经节细胞存活率，因此，可将其用于开发视网膜疾病治疗药物，包括糖尿病视网膜病变、视网膜血管闭塞、早产儿视网膜病变、青光眼等最终会引起视网膜神经节细胞死亡的疾病等。