Floating microsphere for drug delivery and preparation method thereof

The invention relates to the technical field of medical biopolymer materials, in particular to floating microspheres for drug delivery and a preparation method thereof.The preparation raw materials at least comprise a water phase containing gelatin, an oil phase containing an emulsifier and an aldehyde cross-linking agent. The preparation method comprises the following steps: firstly, preparing a micro-emulsion with an oil phase solution containing an emulsifier, and then preparing the multi-unit floating drug delivery microspheres with high drug loading efficiency, ideal drug slow release performance and different drug release efficiencies by adopting an aldehyde cross-linking agent, so that the retention time of the stomach or the bladder of a floating drug delivery system is prolonged. 本发明涉及医用生物高分子材料技术领域，具体为一种用于药物递送的漂浮微球及其制备方法，其制备原料至少包括含有明胶的水相、含有乳化剂的油相、醛类交联剂，将明胶溶于水中得到水相，然后与含有乳化剂的油相溶液形成微乳后采用醛类交联剂制备得到载药效率高，并且具有理想的药物缓释性能的多单元漂浮给药微球，且具有不同的药物释放效率，延长漂浮药物递送系统的胃或膀胱的停留时间。