Preparation method of N-(2-acetaminophenyl)-7-azaindole

The invention discloses a preparation method of N-(2-acetamidophenyl)-7-azaindole. The N-(2-acetamidophenyl)-7-azaindole is prepared According to the method, under a mild condition, N-phenyl-7-azaindole and 3-methyl-1, 4, 2-dioxazole-5-ketone are subjected to a one-step reaction under the mild condition under the condition that [Ru (p-cymene) Cl2] 2 is used as a main catalyst, AgNTf2 is used as a cocatalyst and acetic acid alkali metal salt is used as a reaction assistant, and N-(2-acetaminophenyl)-7-azaindole can be efficiently prepared with high yield. 本发明公开了一种N-（2-乙酰氨基苯基)-7-氮杂吲哚的制备方法。该方法在温和条件下，使N-苯基-7-氮杂吲哚与3-甲基-1,4,2-二恶唑-5-酮在以[Ru(p-cymene)Cl2]2为主催化剂、AgNTf2为助催化剂和乙酸碱金属盐作为反应助剂的情况下，通过在温和条件下一步反应即可高效且高收率地制备N-(2-乙酰氨基苯基)-7-氮杂吲哚。